幸运赛车综合走势图

杨黄恬研究组合作发现小分子化合物ZLN005显著促进人胚胎干细胞源心肌细胞成熟

作者: 2020-04-30 来源:幸运赛车综合走势图|官网
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  2020年4月28日,国际学术期刊 Aging 在线发表了中国科幸运赛车综合走势图上海营养与健康研究所肿瘤与微环境重点实验室杨黄恬研究组与苏州大学第一附属医院陆熙园研究组合作的题为“PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells”的研究论文。该研究报告了PGC-1α激活剂ZLN005显著促进人胚胎干细胞衍生心肌细胞(hESC-CMs)成熟的重要作用和作用机制。研究发现将促进hESC-CMs在疾病模型、药物研发和心肌组织工程中的应用。

  hpsc-cms,baokuoipsclaiyuandexinjixibao(hipsc-cms)hepeitaiganxibaolaiyuandexinjixibao(hesc-cms),zaijibingmoxing、yaowuyanfahexinjisunshangxiufuyuzaishengfangmianjuyoujudadeyingyongjiazhi,danxianyoufangfafenhuahuodedaoxinjixibaochengshudujiaodi,xianzhileqiyingyong。yinci,ruhecujinhipsc-cmsdechengshushizheiyilingyujixujiejuederedianwenti。jinguanyibaodaoduozhongfangfakeyicujinhpsc-cmschengshu,ruzhangshijianpeiyang、dianciji、jixieqianzhang、shenghuaciji、3dcailiaoqianhedeng,danyouyuzheixiefangfachengbengao、haoshijiu,huojishuyaoqiugao,bingbushihedaguimocaokong,erfazhanqixiaokuai、jingji、jianbiankekongdecuhpsc-cmschengshufangfajuyouzhongyaodeyingyongjiazhi。

幸运赛车综合走势图  gaiyanjiujiyuchengrenxinjixibaoyilaiyuxianlitiyanghualinsuanhuachanshengatp,erhpsc-cmszhuyaotongguotangjiaojiechannengdebutongdaixiefangshi,tichucujindaixiezhuanhuanshicujinhpsc-cmschengshudezhiguanzhongyaohuanjiedeshexiang,caiyongkezaizhuanlushuipinggaoxiaojihuodiaokongxianlitidaixiedeperoxisome proliferator-activated receptor gamma coactivator 1α (pgc1α) biaodadexiaofenzihuahewuzln005,faxianqijinchuli2tianjikecongduofangmiancujinhesc-cmschengshu,ruzln005xianzhutigaolepgc1αhehedanbaidebiaodashuiping,tishengxianlitigongnengjiyindebiaoda、daixieshuipinghechengshu。ciwai,zln005chulixianzhushangdiaoyujisiyouguandejiyinbiaoda、gaishanhesc-cmsdejisipailiehezengjiahesc-cmsdejijiezhangdu,cujinxinjixibaojiandejianxilianjiehexinjixibaodedianchuandao,bingshidexinjixibaodedongzuodianweihegaishunbiangengchengshu。yanjiufaxianjieshileyizhonggaoxiao、jingji、jianbiancujinhesc-cmschengshudefangfa,duihesc-cmsdeguangfanyingyongjuyouzhongyaodeyiyi。

  boshiyanjiushengliuyanping(suzhoudaxue)hebaihuajun(shanghaiyingyangyujiankangyanjiusuo)weigongtongdiyizuozhe,luxiyuanjiaoshou(suzhoudaxue)heyanghuangtianyanjiuyuan(shanghaiyingyangyujiankangyanjiusuo)weigongtongtongxunzuozhe。gaixiangyanjiuhaidedaolezhejiangdaxueyixingyunsaichezonghezoushitufushudiyiyiyuanliangpingjiaoshoujituanduichengyuandebangzhu,bingdedaoleguojiazirankexuejijinwei、guojiazhongdianyanfajihuazhuanxiang、zhongguokexingyunsaichezonghezoushituzhanlvexingxiandaokejizhuanxiang、nihbohoujijindezizhu。(kejichu)

  yuanwenlianjie: ;


图示: 小分子化合物ZLN005可多个方面促进hESC-CMs成熟:(A)心肌细胞肌丝结构;(B)心肌细胞肌丝标志基因的表达;(C)心肌细胞电传导;(D)心肌细胞动作电位。

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